KMID : 0525720200250020085
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Journal of Chitin and Chitosan 2020 Volume.25 No. 2 p.85 ~ p.92
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Effect of Sargassum horneri Chloroform Fraction Against Skin Barrier Damage and Skin Moisture Reduction in Ultraviolet B-irradiated Keratinocytes
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Kim Min-Ju
Han Eui-Jeong Lee Kyoung-Hoon Kim Hyun-Soo Ahn Gin-Nae
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Abstract
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The present study was designed to investigate the effect of chloroform fraction of Sargassum horneri methanol extract (SHMC) against skin barrier damage and skin moisture reduction in UVB-irradiated keratinocytes. SHMC increased the cell viability by reducing the intracellular ROS production without cytotoxicity in UVB-irradiated keratinocytes. In addition, SHMC activated the nuclear factor erythroid 2-related factor 2 (Nrf2)/NAD(P)H dehydrogenase [quinone]-1 (NQO-1)/heme oxygenase-1 (HO-1) signaling pathway. Interestingly, the inhibition of HO-1 attenuaed the increment of cell viability, the reduction of intracellular ROS production and the inhibition of NF¥êB activation induced by SHMC. Moreover, SHMC recovered the skin barrier damage and the skin moisture reduction by regulating the expression level of nucleotide-binding oligomerizatin domain (NOD)-like receptor containing pyrin domain 3 (NLRP3, cryopyrin) inflammsome signaling. Collectively, these results suggest that SHMC improved the skin barrier and the skin moisturization in UVB-irradiated keratinocytes.
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KEYWORD
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Sargassum horneri, Ultraviolet B, NLRP3 inflammasome, Skin barrier, Skin moisturization, Keratinocytes
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